Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50162722
Substrate
n/a
Meas. Tech.
ChEMBL_310206 (CHEMBL833811)
EC50
<0.100000±n/a nM
Citation
Fotsch, C; Han, N; Arasasingham, P; Bo, Y; Carmouche, M; Chen, N; Davis, J; Goldberg, MH; Hale, C; Hsieh, FY; Kelly, MG; Liu, Q; Norman, MH; Smith, DM; Stec, M; Tamayo, N; Xi, N; Xu, S; Bannon, AW; Baumgartner, JW Melanocortin subtype-4 receptor agonists containing a piperazine core with substituted aryl sulfonamides. Bioorg Med Chem Lett 15:1623-7 (2005) [PubMed] Article
More Info.:
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Inhibitor
Name:
BDBM50162722
Synonyms:
(S)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-2-(4-{2-[(2-amino-ethyl)-methanesulfonyl-amino]-phenyl}-piperazin-1-yl)-1-(4-chloro-benzyl)-2-oxo-ethyl]-amide | CHEMBL368008
Type:
Small organic molecule
Emp. Form.:
C32H39ClN6O4S
Mol. Mass.:
639.208
SMILES:
CS(=O)(=O)N(CCN)c1ccccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H]1Cc2ccccc2CN1