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Target
Tryptase beta-2
Ligand
BDBM50162763
Substrate
n/a
Meas. Tech.
ChEMBL_304961 (CHEMBL827839)
IC50
5900±n/a nM
Citation
 del Fresno, M; Fernández-Forner, D; Miralpeix, M; Segarra, V; Ryder, H; Royo, M; Albericio, F Combinatorial approaches towards the discovery of new tryptase inhibitors. Bioorg Med Chem Lett 15:1659-64 (2005) [PubMed]  Article 
Target
Name:
Tryptase beta-2
Synonyms:
TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2
Type:
PROTEIN
Mol. Mass.:
30518.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_210702
Residue:
275
Sequence:
MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
  
Inhibitor
Name:
BDBM50162763
Synonyms:
CHEMBL181685 | N-((S)-4-{5-[4-(3-Guanidino-propionylamino)-butyl]-3,6-dioxo-piperazin-2-yl}-butyl)-3-(N-methyl-guanidino)-propionamide
Type:
Small organic molecule
Emp. Form.:
C21H40N10O4
Mol. Mass.:
496.6069
SMILES:
CN(CCC(=O)NCCCC[C@@H]1NC(=O)[C@H](CCCCNC(=O)CCNC(N)=N)NC1=O)C(N)=N
Structure:
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