Reaction Details Report a problem with these data
Target
Tryptase beta-2
Ligand
BDBM50162765
Substrate
n/a
Meas. Tech.
ChEMBL_304961 (CHEMBL827839)
IC50
9300.0±n/a nM
Citation
 del Fresno, M; Fernández-Forner, D; Miralpeix, M; Segarra, V; Ryder, H; Royo, M; Albericio, F Combinatorial approaches towards the discovery of new tryptase inhibitors. Bioorg Med Chem Lett 15:1659-64 (2005) [PubMed]  Article 
Target
Name:
Tryptase beta-2
Synonyms:
TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2
Type:
PROTEIN
Mol. Mass.:
30518.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_210702
Residue:
275
Sequence:
MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
  
Inhibitor
Name:
BDBM50162765
Synonyms:
(S)-N-[4-Guanidino-1-((S)-4-{(S)-5-[4-(5-guanidino-pentanoylamino)-butyl]-3-oxo-6-oxo-piperazin-2-yl}-butylcarbamoyl)-butyl]-benzamide | CHEMBL180712
Type:
Small organic molecule
Emp. Form.:
C31H51N11O5
Mol. Mass.:
657.8073
SMILES:
NC(=N)NCCCCC(=O)NCCCC[C@@H]1NC(=O)[C@H](CCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)c2ccccc2)NC1=O
Structure:
Search PDB for entries with ligand similarity: