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Target
cAMP-dependent protein kinase catalytic subunit PRKX
Ligand
BDBM50429615
Substrate
n/a
Meas. Tech.
ChEMBL_2198940 (CHEMBL5111456)
IC50
580±n/a nM
Citation
 Drewry, DH; Potjewyd, FM; Bayati, A; Smith, JL; Dickmander, RJ; Howell, S; Taft-Benz, S; Min, SM; Hossain, MA; Heise, M; McPherson, PS; Moorman, NJ; Axtman, AD Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of ?-Coronaviruses. J Med Chem 65:12860-12882 (2022) [PubMed] 
Target
Name:
cAMP-dependent protein kinase catalytic subunit PRKX
Synonyms:
PKX1 | PRKX | PRKX_HUMAN | Serine/threonine-protein kinase PRKX
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40897.91
Organism:
Homo sapiens (Human)
Description:
gi_4826948
Residue:
358
Sequence:
MEAPGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF
  
Inhibitor
Name:
BDBM50429615
Synonyms:
CHEMBL2334586
Type:
Small organic molecule
Emp. Form.:
C20H20N4O
Mol. Mass.:
332.399
SMILES:
CC(C)(O)C#Cc1ccc2[nH]c3CCCc4cnc(N)nc4-c3c2c1
Structure:
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