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Target
LIM domain kinase 2
Ligand
BDBM50072664
Substrate
n/a
Meas. Tech.
ChEMBL_2199189 (CHEMBL5111705)
IC50
24±n/a nM
Citation
 Hanke, T; Mathea, S; Woortman, J; Salah, E; Berger, BT; Tumber, A; Kashima, R; Hata, A; Kuster, B; Müller, S; Knapp, S Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes. J Med Chem 65:13264-13287 (2022) [PubMed] 
Target
Name:
LIM domain kinase 2
Synonyms:
LIMK2 | LIMK2_HUMAN
Type:
PROTEIN
Mol. Mass.:
72238.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1514398
Residue:
638
Sequence:
MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP
  
Inhibitor
Name:
BDBM50072664
Synonyms:
CHEMBL3410036
Type:
Small organic molecule
Emp. Form.:
C22H21N5O2
Mol. Mass.:
387.4344
SMILES:
Cc1c[nH]c2ncnc(-c3ccc(NC(=O)N(CCO)c4ccccc4)cc3)c12
Structure:
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