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Target
Ubiquitin carboxyl-terminal hydrolase 8
Ligand
BDBM50591322
Substrate
n/a
Meas. Tech.
ChEMBL_2200010 (CHEMBL5112526)
IC50
1.3±n/a nM
Citation
 Tan, L; Shan, H; Han, C; Zhang, Z; Shen, J; Zhang, X; Xiang, H; Lu, K; Qi, C; Li, Y; Zhuang, G; Chen, G; Tan, L Discovery of Potent OTUB1/USP8 Dual Inhibitors Targeting Proteostasis in Non-Small-Cell Lung Cancer. J Med Chem 65:13645-13659 (2022) [PubMed] 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 8
Synonyms:
Deubiquitinating enzyme 8 | KIAA0055 | UBP8_HUMAN | UBPY | USP8 | Ubiquitin isopeptidase Y | Ubiquitin thioesterase 8 | Ubiquitin-specific-processing protease 8 | hUBPy
Type:
PROTEIN
Mol. Mass.:
127547.92
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105200
Residue:
1118
Sequence:
MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAYVLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEAERLSESLKLRYEEAEVRKKLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEKGAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLPDDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVLRNEPLVLEGGYENWLLCYPQYTTNAKVTPPPRRQNEEVSISLDFTYPSLEESIPSKPAAQTPPASIEVDENIELISGQNERMGPLNISTPVEPVAASKSDVSPIIQPVPSIKNVPQIDRTKKPAVKLPEEHRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKARIHAETALLMEKNKQEKELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKETSAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSGKPFKIKGQPESGILRTGTFREDTDDTERNKAQREPLTRARSEEMGRIVPGLPSGWAKFLDPITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSPDITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYTSLGPRVTDVAT
  
Inhibitor
Name:
BDBM50591322
Synonyms:
CHEMBL5196686
Type:
Small organic molecule
Emp. Form.:
C22H17ClN2O4
Mol. Mass.:
408.834
SMILES:
CN1CC[C@H](C1)Oc1ccc(Cl)c(c1)-c1nc2c(o1)C(=O)c1ccccc1C2=O |r|
Structure:
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