Reaction Details Report a problem with these data
Target
Ataxin-3
Ligand
BDBM50591322
Substrate
n/a
Meas. Tech.
ChEMBL_2200015 (CHEMBL5112531)
IC50
>10000±n/a nM
Citation
 Tan, L; Shan, H; Han, C; Zhang, Z; Shen, J; Zhang, X; Xiang, H; Lu, K; Qi, C; Li, Y; Zhuang, G; Chen, G; Tan, L Discovery of Potent OTUB1/USP8 Dual Inhibitors Targeting Proteostasis in Non-Small-Cell Lung Cancer. J Med Chem 65:13645-13659 (2022) [PubMed] 
Target
Name:
Ataxin-3
Synonyms:
3.4.19.12 | ATX3 | ATX3_HUMAN | ATXN3 | Ataxin-3 | MJD | MJD1 | Machado-Joseph disease protein 1 | SCA3 | Spinocerebellar ataxia type 3 protein
Type:
PROTEIN
Mol. Mass.:
41227.92
Organism:
Homo sapiens
Description:
ChEMBL_118990
Residue:
361
Sequence:
MESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERMRMAEGGVTSEDYRTFLQQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQAAVTMSLETVRNDLKTEGKK
  
Inhibitor
Name:
BDBM50591322
Synonyms:
CHEMBL5196686
Type:
Small organic molecule
Emp. Form.:
C22H17ClN2O4
Mol. Mass.:
408.834
SMILES:
CN1CC[C@H](C1)Oc1ccc(Cl)c(c1)-c1nc2c(o1)C(=O)c1ccccc1C2=O |r|
Structure:
Search PDB for entries with ligand similarity: