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Target
Neutrophil collagenase
Ligand
BDBM50163799
Substrate
n/a
Meas. Tech.
ChEMBL_305082 (CHEMBL832712)
IC50
31±n/a nM
Citation
 Blagg, JA; Noe, MC; Wolf-Gouveia, LA; Reiter, LA; Laird, ER; Chang, SP; Danley, DE; Downs, JT; Elliott, NC; Eskra, JD; Griffiths, RJ; Hardink, JR; Haugeto, AI; Jones, CS; Liras, JL; Lopresti-Morrow, LL; Mitchell, PG; Pandit, J; Robinson, RP; Subramanyam, C; Vaughn-Bowser, ML; Yocum, SA Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14. Bioorg Med Chem Lett 15:1807-10 (2005) [PubMed]  Article 
Target
Name:
Neutrophil collagenase
Synonyms:
CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:
Enzyme
Mol. Mass.:
53413.48
Organism:
Homo sapiens (Human)
Description:
P22894
Residue:
467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
  
Inhibitor
Name:
BDBM50163799
Synonyms:
5-Amino-3-(2-ethoxy-ethyl)-3-[4-(4-[1,3,4]oxadiazol-2-yl-phenoxy)-phenoxy]-piperidine-2,4,6-trione | CHEMBL183410
Type:
Small organic molecule
Emp. Form.:
C23H22N4O7
Mol. Mass.:
466.4434
SMILES:
CCOCCC1(Oc2ccc(Oc3ccc(cc3)-c3nnco3)cc2)C(=O)NC(=O)C(N)C1=O
Structure:
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