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Target
Cytochrome P450 4F2
Ligand
BDBM50591501
Substrate
n/a
Meas. Tech.
ChEMBL_2200604 (CHEMBL5113120)
IC50
15±n/a nM
Citation
 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition. J Med Chem 65:14599-14613 (2022) [PubMed] 
Target
Name:
Cytochrome P450 4F2
Synonyms:
20-HETE synthase | 20-hydroxyeicosatetraenoic acid synthase | Arachidonic acid omega-hydroxylase | CP4F2_HUMAN | CYP4F2 | CYPIVF2 | Cytochrome P450 4F2 | Cytochrome P450-LTB-omega | Leukotriene-B(4) 20-monooxygenase 1 | Leukotriene-B(4) omega-hydroxylase 1 | Phylloquinone omega-hydroxylase CYP4F2
Type:
PROTEIN
Mol. Mass.:
59859.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_10743
Residue:
520
Sequence:
MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS
  
Inhibitor
Name:
BDBM50591501
Synonyms:
CHEMBL5183418
Type:
Small organic molecule
Emp. Form.:
C16H12N4O
Mol. Mass.:
276.2927
SMILES:
N#Cc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1
Structure:
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