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Target
Prothrombin
Ligand
BDBM50164266
Substrate
n/a
Meas. Tech.
ChEMBL_302313 (CHEMBL828902)
Ki
3.1±n/a nM
Citation
 Stauffer, KJ; Williams, PD; Selnick, HG; Nantermet, PG; Newton, CL; Homnick, CF; Zrada, MM; Lewis, SD; Lucas, BJ; Krueger, JA; Pietrak, BL; Lyle, EA; Singh, R; Miller-Stein, C; White, RB; Wong, B; Wallace, AA; Sitko, GR; Cook, JJ; Holahan, MA; Stranieri-Michener, M; Leonard, YM; Lynch, JJ; McMasters, DR; Yan, Y 9-hydroxyazafluorenes and their use in thrombin inhibitors. J Med Chem 48:2282-93 (2005) [PubMed]  Article 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  
Inhibitor
Name:
BDBM50164266
Synonyms:
(S)-1-(9-Hydroxy-9H-fluorene-9-carbonyl)-pyrrolidine-2-carboxylic acid 2-(2-amino-ethyl)-5-chloro-benzylamide | CHEMBL193188
Type:
Small organic molecule
Emp. Form.:
C28H28ClN3O3
Mol. Mass.:
489.993
SMILES:
NCCc1ccc(Cl)cc1CNC(=O)[C@@H]1CCCN1C(=O)C1(O)c2ccccc2-c2ccccc12
Structure:
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