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Target
Amine oxidase [flavin-containing] A
Ligand
BDBM50005251
Substrate
n/a
Meas. Tech.
ChEMBL_305534 (CHEMBL828554)
IC50
>100000±n/a nM
Citation
 Gallardo-Godoy, A; Fierro, A; McLean, TH; Castillo, M; Cassels, BK; Reyes-Parada, M; Nichols, DE Sulfur-substituted alpha-alkyl phenethylamines as selective and reversible MAO-A inhibitors: biological activities, CoMFA analysis, and active site modeling. J Med Chem 48:2407-19 (2005) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_RAT | Amine oxidase (flavin-containing) A | Amine oxidase [flavin-containing] A | Maoa | Monoamine Oxidase Type A (MAO-A) | Monoamine oxidase | Monoamine oxidase A (MAO-A) | Monoamine oxidase A (rMAO-A) | Monoamine oxidase type A (MAOA)
Type:
Enzyme
Mol. Mass.:
59515.21
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
526
Sequence:
MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKDVPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLPC
  
Inhibitor
Name:
BDBM50005251
Synonyms:
(+/-)2-(2,5-Dimethoxy-phenyl)-1-methyl-ethylamine | 1-(2,5-dimethoxyphenyl)propan-2-amine | 2,5-dimethoxy-4-bromoamphetamine | 2-(2,5-Dimethoxy-phenyl)-1-methyl-ethylamine | 2-(2,5-Dimethoxy-phenyl)-1-methyl-ethylamine(2,5-DMA) | CHEMBL8642 | DMA
Type:
Small organic molecule
Emp. Form.:
C11H17NO2
Mol. Mass.:
195.2582
SMILES:
COc1ccc(OC)c(CC(C)N)c1
Structure:
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