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Target
Reverse transcriptase/RNaseH
Ligand
BDBM50591801
Substrate
n/a
Meas. Tech.
ChEMBL_2201744 (CHEMBL5114452)
IC50
300±n/a nM
Citation
 Popovi?-Djordjevi?, J; Quispe, C; Giordo, R; Kosti?, A; Katani? Stankovi?, JS; Tsouh Fokou, PV; Carbone, K; Martorell, M; Kumar, M; Pintus, G; Sharifi-Rad, J; Docea, AO; Calina, D Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs. Eur J Med Chem 233:0 (2022) [PubMed] 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM50591801
Synonyms:
CHEMBL5207632
Type:
Small organic molecule
Emp. Form.:
C16H11ClN2O2S2
Mol. Mass.:
362.854
SMILES:
Oc1ccc(cc1)C1SCC(=O)N1c1nc2ccc(Cl)cc2s1
Structure:
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