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Target
14-3-3 protein eta
Ligand
BDBM50591815
Substrate
n/a
Meas. Tech.
ChEMBL_2201840 (CHEMBL5114548)
Kd
56000±n/a nM
Citation
 Gao, Z; Fan, T; Chen, L; Yang, M; Wai Wong, VK; Chen, D; Liu, Z; Zhou, Y; Wu, W; Qiu, Z; Zhang, C; Li, Y; Jiang, Y Design, synthesis and antitumor evaluation of novel 1H-indole-2-carboxylic acid derivatives targeting 14-3-3? protein. Eur J Med Chem 238:0 (2022) [PubMed] 
Target
Name:
14-3-3 protein eta
Synonyms:
14-3-3 protein eta | 1433F_HUMAN | Protein AS1 | YWHA1 | YWHAH
Type:
PROTEIN
Mol. Mass.:
28205.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_110546
Residue:
246
Sequence:
MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLSLLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEASEAAYKEAFEISKEQMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDEEAGEGN
  
Inhibitor
Name:
BDBM50591815
Synonyms:
CHEMBL5207241
Type:
Small organic molecule
Emp. Form.:
C27H26N2O5
Mol. Mass.:
458.5057
SMILES:
COc1ccc(Cn2c(C(O)=O)c(CNC(=O)c3cccc(OC)c3)c3ccc(C)cc23)cc1
Structure:
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