Reaction Details Report a problem with these data
Target
14-3-3 protein eta
Ligand
BDBM50591820
Substrate
n/a
Meas. Tech.
ChEMBL_2201840 (CHEMBL5114548)
Kd
>200000±n/a nM
Citation
 Gao, Z; Fan, T; Chen, L; Yang, M; Wai Wong, VK; Chen, D; Liu, Z; Zhou, Y; Wu, W; Qiu, Z; Zhang, C; Li, Y; Jiang, Y Design, synthesis and antitumor evaluation of novel 1H-indole-2-carboxylic acid derivatives targeting 14-3-3? protein. Eur J Med Chem 238:0 (2022) [PubMed] 
Target
Name:
14-3-3 protein eta
Synonyms:
14-3-3 protein eta | 1433F_HUMAN | Protein AS1 | YWHA1 | YWHAH
Type:
PROTEIN
Mol. Mass.:
28205.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_110546
Residue:
246
Sequence:
MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLSLLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEASEAAYKEAFEISKEQMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDEEAGEGN
  
Inhibitor
Name:
BDBM50591820
Synonyms:
CHEMBL5187121
Type:
Small organic molecule
Emp. Form.:
C26H25FN2O3
Mol. Mass.:
432.4867
SMILES:
COc1cccc(CNCc2c(C(O)=O)n(Cc3ccccc3F)c3cc(C)ccc23)c1
Structure:
Search PDB for entries with ligand similarity: