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Target
Cyclin-dependent kinase 11A
Ligand
BDBM50592069
Substrate
n/a
Meas. Tech.
ChEMBL_2203151 (CHEMBL5115859)
IC50
2200±n/a nM
Citation
 Li, Z; Ishida, R; Liu, Y; Wang, J; Li, Y; Gao, Y; Jiang, J; Che, J; Sheltzer, JM; Robers, MB; Zhang, T; Westover, KD; Nabet, B; Gray, NS Synthesis and Structure-Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold. Eur J Med Chem 238:0 (2022) [PubMed] 
Target
Name:
Cyclin-dependent kinase 11A
Synonyms:
CD11A_HUMAN | CDC2L2 | CDC2L3 | CDK11A | Cell division cycle 2-like protein kinase 2 | Cell division protein kinase 11A | Galactosyltransferase-associated protein kinase p58/GTA | PITSLRE serine/threonine-protein kinase CDC2L2 | PITSLREB
Type:
PROTEIN
Mol. Mass.:
91334.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774613
Residue:
783
Sequence:
MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
  
Inhibitor
Name:
BDBM50592069
Synonyms:
CHEMBL5177982
Type:
Small organic molecule
Emp. Form.:
C21H21Cl2N5O2S
Mol. Mass.:
478.395
SMILES:
Cc1nc(ccc1Nc1nc(N)c(s1)C(=O)c1c(Cl)cccc1Cl)N1CCC(O)CC1
Structure:
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