Reaction Details Report a problem with these data
Target
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
Ligand
BDBM50592071
Substrate
n/a
Meas. Tech.
ChEMBL_2203173 (CHEMBL5115881)
IC50
6200±n/a nM
Citation
 Fang, Z; Mu, B; Liu, Y; Guo, N; Xiong, L; Guo, Y; Xia, A; Zhang, R; Zhang, H; Yao, R; Fan, Y; Li, L; Yang, S; Xiang, R Discovery of a potent, selective and cell active inhibitor of m Eur J Med Chem 238:0 (2022) [PubMed] 
Target
Name:
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
Synonyms:
ABH3 | ALKB3_HUMAN | ALKBH3 | Alkylated DNA repair protein alkB homolog 3 | DEPC-1 | DEPC1 | Prostate cancer antigen 1
Type:
PROTEIN
Mol. Mass.:
33382.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108024
Residue:
286
Sequence:
MEEKRRRARVQGAWAAPVKSQAIAQPATTAKSHLHQKPGQTWKNKEHHLSDREFVFKEPQQVVRRAPEPRVIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLCQDVPWKQRTGIREDITYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLRTLKNRIEENTGHTFNSLLCNLYRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRTFEMRKKPPPEENGDYTYVERVKIPLDHGTLLIMEGATQADWQHRVPKEYHSREPRVNLTFRTVYPDPRGAPW
  
Inhibitor
Name:
BDBM50592071
Synonyms:
CHEMBL5169684
Type:
Small organic molecule
Emp. Form.:
C13H9N3O7S
Mol. Mass.:
351.291
SMILES:
OC(=O)c1ccnc(c1)C(=O)NS(=O)(=O)c1ccccc1[N+]([O-])=O
Structure:
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