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Target
Dual specificity protein kinase CLK4
Ligand
BDBM50592236
Substrate
n/a
Meas. Tech.
ChEMBL_2203500 (CHEMBL5116208)
IC50
6.6±n/a nM
Citation
 El-Gamil, DS; ElHady, AK; Chen, PJ; Hwang, TL; Abadi, AH; Abdel-Halim, M; Engel, M Development of novel conformationally restricted selective Clk1/4 inhibitors through creating an intramolecular hydrogen bond involving an imide linker. Eur J Med Chem 238:0 (2022) [PubMed] 
Target
Name:
Dual specificity protein kinase CLK4
Synonyms:
CDC-like kinase 4 | CLK4 | CLK4_HUMAN | Dual specificity protein kinase CLK1/CLK4
Type:
Serine/threonine-protein kinase
Mol. Mass.:
57522.53
Organism:
Homo sapiens (Human)
Description:
gi_10190706
Residue:
481
Sequence:
MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK
  
Inhibitor
Name:
BDBM50592236
Synonyms:
CHEMBL5206943
Type:
Small organic molecule
Emp. Form.:
C18H14ClNO4S
Mol. Mass.:
375.826
SMILES:
COc1ccc2sc(cc2c1)C(=O)NC(=O)c1cc(Cl)ccc1OC
Structure:
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