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Target
Potassium voltage-gated channel subfamily KQT member 5
Ligand
BDBM50592355
Substrate
n/a
Meas. Tech.
ChEMBL_2203876 (CHEMBL5116584)
EC50
3780±n/a nM
Citation
 Hernandez, CC; Tarfa, RA; Miguel I Limcaoco, J; Liu, R; Mondal, P; Hill, C; Keith Duncan, R; Tzounopoulos, T; Stephenson, CRJ; O'Meara, MJ; Wipf, P Development of an automated screen for Kv7.2 potassium channels and discovery of a new agonist chemotype. Bioorg Med Chem Lett 71:0 (2022) [PubMed] 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 5
Synonyms:
KCNQ (Kv7) potassium channel | KCNQ5 | KCNQ5_HUMAN | Voltage-gated potassium channel subunit Kv7.5
Type:
PROTEIN
Mol. Mass.:
102221.23
Organism:
Homo sapiens (Human)
Description:
ChEMBL_938650
Residue:
932
Sequence:
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLLGKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWKPHLKALHTCSPTKKEQGEASSSQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQPKPVIDADTALGTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQITSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFECEQTSDYQSPVDSKDLSGSAQNSGCLSRSTSANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQSDGSAVAATNTIANQINTAPKPAAPTTLQIPPPLPAIKHLPRPETLHPNPAGLQESISDVTTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTEELNIQLSGSESSGSRGSQDFYPKWRESKLFITDEEVGPEETETDTFDAAPQPAREAAFASDSLRTGRSRSSQSICKAGESTDALSLPHVKLK
  
Inhibitor
Name:
BDBM50592355
Synonyms:
CHEMBL5200636
Type:
Small organic molecule
Emp. Form.:
C17H13F7N4O2
Mol. Mass.:
438.2995
SMILES:
Nc1c(F)c(NCc2ncc(cc2F)C(F)(F)F)c(F)c(F)c1NC(=O)OC1CC1
Structure:
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