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Target
Cytochrome c oxidase subunit 2
Ligand
BDBM50592557
Substrate
n/a
Meas. Tech.
ChEMBL_2204444 (CHEMBL5117152)
IC50
3550±n/a nM
Citation
 Hu, X; Li, J; Zhang, H; Yu, Q; Wang, Y; Li, X; Long, L; Jiang, W; Wang, Z Discovery of dual inhibitors of topoisomerase I and Cyclooxygenase-2 for colon cancer therapy. Eur J Med Chem 240:0 (2022) [PubMed] 
Target
Name:
Cytochrome c oxidase subunit 2
Synonyms:
COII | COX2 | COX2_HUMAN | COXII | MT-CO2 | MTCO2
Type:
PROTEIN
Mol. Mass.:
25555.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_530099
Residue:
227
Sequence:
MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGHQWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVLHSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL
  
Inhibitor
Name:
BDBM50592557
Synonyms:
CHEMBL5183520
Type:
Small organic molecule
Emp. Form.:
C27H31ClN4O
Mol. Mass.:
463.014
SMILES:
CC(C)N1CCN(CC1)c1ccc(NC(=O)c2ccccc2Nc2cccc(Cl)c2C)cc1
Structure:
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