Reaction Details Report a problem with these data
Target
Heparanase
Ligand
BDBM50165646
Substrate
n/a
Meas. Tech.
ChEMBL_305497 (CHEMBL831099)
IC50
2500±n/a nM
Citation
Courtney, SM; Hay, PA; Buck, RT; Colville, CS; Phillips, DJ; Scopes, DI; Pollard, FC; Page, MJ; Bennett, JM; Hircock, ML; McKenzie, EA; Bhaman, M; Felix, R; Stubberfield, CR; Turner, PR Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivatives: novel classes of heparanase inhibitor. Bioorg Med Chem Lett 15:2295-9 (2005) [PubMed] Article
More Info.:
Target
Name:
Heparanase
Synonyms:
Endo-glucoronidase | HEP | HPA | HPA1 | HPR1 | HPSE | HPSE1 | HPSE_HUMAN | HSE1 | Heparanase 50 kDa subunit | Heparanase 8 kDa subunit | Heparanase-1
Type:
PROTEIN
Mol. Mass.:
61167.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_327900
Residue:
543
Sequence:
MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVTIDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQSQVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGSQLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYLNGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFAAGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLMASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLLRPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVAACI
Inhibitor
Name:
BDBM50165646
Synonyms:
(2-{2-Chloro-4-[3-((E)-3-methoxy-phenyl)-acryloylamino]-phenyl}-benzooxazol-5-yl)-acetic acid | 2-(2-(2-chloro-4-(3-(3-methoxyphenyl)acrylamido)phenyl)benzo[d]oxazol-5-yl)acetic acid | CHEMBL196394
Type:
Small organic molecule
Emp. Form.:
C25H19ClN2O5
Mol. Mass.:
462.882
SMILES:
COc1cccc(\C=C\C(=O)Nc2ccc(-c3nc4cc(CC(O)=O)ccc4o3)c(Cl)c2)c1