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Target
Heparanase
Ligand
BDBM50165613
Substrate
n/a
Meas. Tech.
ChEMBL_305497 (CHEMBL831099)
IC50
400±n/a nM
Citation
 Courtney, SM; Hay, PA; Buck, RT; Colville, CS; Phillips, DJ; Scopes, DI; Pollard, FC; Page, MJ; Bennett, JM; Hircock, ML; McKenzie, EA; Bhaman, M; Felix, R; Stubberfield, CR; Turner, PR Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivatives: novel classes of heparanase inhibitor. Bioorg Med Chem Lett 15:2295-9 (2005) [PubMed]  Article 
Target
Name:
Heparanase
Synonyms:
Heparanase-1 | Heparanase 50 kDa subunit | Heparanase 8 kDa subunit | Endo-glucoronidase | HEP | HPA | HPA1 | HPR1 | HPSE1 | HSE1 | HPSE_HUMAN | HPSE
Type:
PROTEIN
Mol. Mass.:
61167.67
Organism:
Human
Description:
ChEMBL_327900
Residue:
543
Sequence:
MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVTIDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQSQVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGSQLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYLNGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFAAGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLMASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLLRPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVAACI
  
Inhibitor
Name:
BDBM50165613
Synonyms:
2-(2-(4-(3-(4-bromophenyl)acrylamido)-2-chlorophenyl)benzo[d]oxazol-5-yl)acetic acid | (2-{4-[3-((E)-4-Bromo-phenyl)-acryloylamino]-2-chloro-phenyl}-benzooxazol-5-yl)-acetic acid | CHEMBL195663
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
OC(=O)Cc1ccc2oc(nc2c1)-c1ccc(NC(=O)\C=C\c2ccc(Br)cc2)cc1Cl
Structure:
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