Reaction Details Report a problem with these data
Target
Heparanase
Ligand
BDBM50165635
Substrate
n/a
Meas. Tech.
ChEMBL_305497 (CHEMBL831099)
IC50
1500±n/a nM
Citation
Courtney, SM; Hay, PA; Buck, RT; Colville, CS; Phillips, DJ; Scopes, DI; Pollard, FC; Page, MJ; Bennett, JM; Hircock, ML; McKenzie, EA; Bhaman, M; Felix, R; Stubberfield, CR; Turner, PR Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivatives: novel classes of heparanase inhibitor. Bioorg Med Chem Lett 15:2295-9 (2005) [PubMed] Article
More Info.:
Target
Name:
Heparanase
Synonyms:
Endo-glucoronidase | HEP | HPA | HPA1 | HPR1 | HPSE | HPSE1 | HPSE_HUMAN | HSE1 | Heparanase 50 kDa subunit | Heparanase 8 kDa subunit | Heparanase-1
Type:
PROTEIN
Mol. Mass.:
61167.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_327900
Residue:
543
Sequence:
MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVTIDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQSQVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGSQLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYLNGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFAAGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLMASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLLRPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVAACI
Inhibitor
Name:
BDBM50165635
Synonyms:
(4-{5-[2-Chloro-4-(4-trifluoromethoxy-benzoylamino)-phenyl]-furan-2-yl}-thiazol-2-yl)-acetic acid | 2-(4-(5-(2-chloro-4-(4-(trifluoromethoxy)benzamido)phenyl)furan-2-yl)thiazol-2-yl)acetic acid | CHEMBL192463
Type:
Small organic molecule
Emp. Form.:
C23H14ClF3N2O5S
Mol. Mass.:
522.881
SMILES:
OC(=O)Cc1nc(cs1)-c1ccc(o1)-c1ccc(NC(=O)c2ccc(OC(F)(F)F)cc2)cc1Cl