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Target
Dual specificity mitogen-activated protein kinase kinase 6
Ligand
BDBM50592884
Substrate
n/a
Meas. Tech.
ChEMBL_2205891 (CHEMBL5118599)
IC50
<1000±n/a nM
Citation
 Juchum, M; Pfaffenrot, B; Klövekorn, P; Selig, R; Albrecht, W; Zender, L; Laufer, SA Scaffold modified Vemurafenib analogues as highly selective mitogen activated protein kinase kinase 4 (MKK4) inhibitors. Eur J Med Chem 240:0 (2022) [PubMed] 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 6
Synonyms:
Dual specificity mitogen-activated protein kinase kinase 6 | MAP kinase kinase 6 | MAP2K6 | MAPK/ERK kinase 6 | MAPKK 6 | MEK6 | MKK6 | MP2K6_HUMAN | Mitogen-activated protein kinase kinase 6 (MKK6) | PRKMK6 | SAPKK3 | SKK3
Type:
Protein
Mol. Mass.:
37494.96
Organism:
Homo sapiens (Human)
Description:
P52564
Residue:
334
Sequence:
MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
  
Inhibitor
Name:
BDBM50592884
Synonyms:
CHEMBL3716507
Type:
Small organic molecule
Emp. Form.:
C17H12N4O
Mol. Mass.:
288.3034
SMILES:
NC(=O)c1ccc2[nH]c3ncnc(-c4ccccc4)c3c2c1
Structure:
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