Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50165732
Substrate
n/a
Meas. Tech.
ChEMBL_302315 (CHEMBL840829)
Ki
8300.0±n/a nM
Citation
 Almajan, GL; Innocenti, A; Puccetti, L; Manole, G; Barbuceanu, S; Saramet, I; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols. Bioorg Med Chem Lett 15:2347-52 (2005) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50165732
Synonyms:
5-(4-Nitro-phenylsulfanylamino)-[1,3,4]thiadiazole-2-thiol | CHEMBL193436
Type:
Small organic molecule
Emp. Form.:
C8H6N4O2S3
Mol. Mass.:
286.354
SMILES:
[O-][N+](=O)c1ccc(SNc2n[n-]c(=[SH+])s2)cc1
Structure:
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