Reaction Details
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D(4) dopamine receptor
Ligand
BDBM50592919
Substrate
n/a
Meas. Tech.
ChEMBL_2206542 (CHEMBL5119250)
Ki
5.5±n/a nM
Citation
García-Cárceles, J; Vázquez-Villa, H; Brea, J; Ladron de Guevara-Miranda, D; Cincilla, G; Sánchez-Martínez, M; Sánchez-Merino, A; Algar, S; Teresa de Los Frailes, M; Roberts, RS; Ballesteros, JA; Rodríguez de Fonseca, F; Benhamú, B; Loza, MI; López-Rodríguez, ML 2-(Fluoromethoxy)-4'-( J Med Chem 65:12256-12272 (2022) [PubMed] More Info.:
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
Inhibitor
Name:
BDBM50592919
Synonyms:
CHEMBL5187578
Type:
Small organic molecule
Emp. Form.:
C14H11FO2
Mol. Mass.:
230.2343
SMILES:
FCOc1ccccc1-c1ccc(C=O)cc1
Structure:
