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Target
Delta-type opioid receptor
Ligand
BDBM50166344
Substrate
n/a
Meas. Tech.
ChEMBL_303398 (CHEMBL840061)
Ki
>10000±n/a nM
Citation
 Sperlinga, E; Kosson, P; Urbanczyk-Lipkowska, Z; Ronsisvalle, G; Carr, DB; Lipkowski, AW 6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid mimics active conformation of tyrosine in opioid peptides. Bioorg Med Chem Lett 15:2467-9 (2005) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | OPRD_RAT | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Opioid receptors; mu & delta | Oprd1 | Ror-a | Voltage-gated potassium channel
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40465.04
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor.
Residue:
372
Sequence:
MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50166344
Synonyms:
7-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-[(S)-1-({[(S)-2-[(S)-2-((S)-1-carbamoyl-2-hydroxy-ethylcarbamoyl)-pyrrolidin-1-yl]-1-(4-hydroxy-benzyl)-2-oxo-ethylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-ethyl}-amide | CHEMBL194154
Type:
Small organic molecule
Emp. Form.:
C41H50N8O10
Mol. Mass.:
814.8833
SMILES:
C[C@@H](NC(=O)C1Cc2ccc(O)cc2CN1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O
Structure:
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