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Target
Delta-type opioid receptor
Ligand
BDBM50166347
Substrate
n/a
Meas. Tech.
ChEMBL_303398 (CHEMBL840061)
Ki
10.4±n/a nM
Citation
 Sperlinga, E; Kosson, P; Urbanczyk-Lipkowska, Z; Ronsisvalle, G; Carr, DB; Lipkowski, AW 6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid mimics active conformation of tyrosine in opioid peptides. Bioorg Med Chem Lett 15:2467-9 (2005) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | OPRD_RAT | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Opioid receptors; mu & delta | Oprd1 | Ror-a | Voltage-gated potassium channel
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40465.04
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor.
Residue:
372
Sequence:
MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50166347
Synonyms:
(S)-N-{(S)-1-[(S)-1-(Carbamoylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propyl}-3-((S)-2-{(R)-2-[((S)-6-hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl)-amino]-propionylamino}-3-phenyl-propionylamino)-succinamic acid | CHEMBL191777
Type:
Small organic molecule
Emp. Form.:
C38H52N8O10
Mol. Mass.:
780.8671
SMILES:
CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H]1Cc2cc(O)ccc2CN1)C(C)C)C(=O)NCC(N)=O
Structure:
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