Target
RNA-directed RNA polymerase
Ligand
BDBM50166360
Substrate
n/a
Meas. Tech.
ChEMBL_305065 (CHEMBL832697)
IC50
40±n/a nM
Citation
 Pfefferkorn, JAGreene, MLNugent, RAGross, RJMitchell, MAFinzel, BCHarris, MSWells, PAShelly, JAAnstadt, RAKilkuskie, REKopta, LASchwende, FJ Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid. Bioorg Med Chem Lett 15:2481-6 (2005) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50166360
Synonyms:
(Z)-2-Benzoylamino-3-[4-(2-iodo-phenoxy)-phenyl]-acrylic acid | CHEMBL370679
Type:
Small organic molecule
Emp. Form.:
C22H16INO4
Mol. Mass.:
485.2712
SMILES:
OC(=O)C(\NC(=O)c1ccccc1)=C\c1ccc(Oc2ccccc2I)cc1
Structure:
Search PDB for entries with ligand similarity: