Reaction Details Report a problem with these data
Target
RNA-directed RNA polymerase
Ligand
BDBM50166367
Substrate
n/a
Meas. Tech.
ChEMBL_305065 (CHEMBL832697)
IC50
1400±n/a nM
Citation
 Pfefferkorn, JA; Greene, ML; Nugent, RA; Gross, RJ; Mitchell, MA; Finzel, BC; Harris, MS; Wells, PA; Shelly, JA; Anstadt, RA; Kilkuskie, RE; Kopta, LA; Schwende, FJ Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid. Bioorg Med Chem Lett 15:2481-6 (2005) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50166367
Synonyms:
(Z)-2-Benzoylamino-3-(5-o-tolyl-thiophen-2-yl)-acrylic acid | CHEMBL373120
Type:
Small organic molecule
Emp. Form.:
C21H17NO3S
Mol. Mass.:
363.43
SMILES:
Cc1ccccc1-c1ccc(\C=C(/NC(=O)c2ccccc2)C(O)=O)s1
Structure:
Search PDB for entries with ligand similarity: