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Target
RNA-directed RNA polymerase
Ligand
BDBM50166384
Substrate
n/a
Meas. Tech.
ChEMBL_305065 (CHEMBL832697)
IC50
1300±n/a nM
Citation
 Pfefferkorn, JA; Greene, ML; Nugent, RA; Gross, RJ; Mitchell, MA; Finzel, BC; Harris, MS; Wells, PA; Shelly, JA; Anstadt, RA; Kilkuskie, RE; Kopta, LA; Schwende, FJ Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid. Bioorg Med Chem Lett 15:2481-6 (2005) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50166384
Synonyms:
(Z)-2-Benzoylamino-3-[4-(2-trifluoromethyl-phenoxy)-phenyl]-acrylic acid | CHEMBL371410
Type:
Small organic molecule
Emp. Form.:
C23H16F3NO4
Mol. Mass.:
427.3726
SMILES:
OC(=O)C(\NC(=O)c1ccccc1)=C\c1ccc(Oc2ccccc2C(F)(F)F)cc1
Structure:
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