Reaction Details Report a problem with these data
Target
Melanocortin receptor 3
Ligand
BDBM50166544
Substrate
n/a
Meas. Tech.
ChEMBL_303455 (CHEMBL839715)
Ki
790±n/a nM
Citation
 Pontillo, J; Tran, JA; Markison, S; Joppa, M; Fleck, BA; Marinkovic, D; Arellano, M; Tucci, FC; Lanier, M; Nelson, J; Saunders, J; Hoare, SR; Foster, AC; Chen, C A potent and selective nonpeptide antagonist of the melanocortin-4 receptor induces food intake in satiated mice. Bioorg Med Chem Lett 15:2541-6 (2005) [PubMed]  Article 
Target
Name:
Melanocortin receptor 3
Synonyms:
MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4)
Type:
Enzyme
Mol. Mass.:
36044.86
Organism:
Homo sapiens (Human)
Description:
P41968
Residue:
323
Sequence:
MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG
  
Inhibitor
Name:
BDBM50166544
Synonyms:
1-[(R)-1-(2,4-Dichloro-benzyl)-2-oxo-2-(4-{2-[(2-thiophen-2-yl-ethylamino)-methyl]-phenyl}-piperazin-1-yl)-ethyl]-3-ethyl-urea | CHEMBL363576
Type:
Small organic molecule
Emp. Form.:
C29H35Cl2N5O2S
Mol. Mass.:
588.592
SMILES:
CCNC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1
Structure:
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