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Target
E3 ubiquitin-protein ligase CBL-B
Ligand
BDBM50593286
Substrate
n/a
Meas. Tech.
ChEMBL_2207896 (CHEMBL5120604)
IC50
6.0±n/a nM
Citation
 Sabnis, RW Novel Lactams as Cbl-b Inhibitors for Treating Cancer. ACS Med Chem Lett 13:1556-1557 (2022) [PubMed] 
Target
Name:
E3 ubiquitin-protein ligase CBL-B
Synonyms:
2.3.2.27 | CBLB | CBLB_HUMAN | Casitas B-lineage lymphoma proto-oncogene b | RING finger protein 56 | RING-type E3 ubiquitin transferase CBL-B | RNF56 | SH3-binding protein CBL-B | Signal transduction protein CBL-B
Type:
PROTEIN
Mol. Mass.:
109467.65
Organism:
Homo sapiens
Description:
ChEMBL_120423
Residue:
982
Sequence:
MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL
  
Inhibitor
Name:
BDBM50593286
Synonyms:
CHEMBL5178829
Type:
Small organic molecule
Emp. Form.:
C31H37F3N6O
Mol. Mass.:
566.6603
SMILES:
CCNc1cc(cc(c1)C1(Cc2nncn2C)CCC1)N1Cc2c(cc(CNC3(C)CCC3)cc2C(F)(F)F)C1=O
Structure:
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