Reaction Details Report a problem with these data
Target
NAD kinase
Ligand
BDBM50295365
Substrate
n/a
Meas. Tech.
ChEMBL_2207955 (CHEMBL5120663)
Ki
6000±n/a nM
Citation
 Liu, T; Shi, W; Ding, Y; Wu, Q; Zhang, B; Zhang, N; Wang, M; Du, D; Zhang, H; Han, B; Guo, D; Zheng, J; Li, Q; Luo, C (-)-Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase. ACS Med Chem Lett 13:1699-1706 (2022) [PubMed] 
Target
Name:
NAD kinase
Synonyms:
NADK | NADK_HUMAN
Type:
PROTEIN
Mol. Mass.:
49227.18
Organism:
Homo sapiens (Human)
Description:
ChEMBL_578494
Residue:
446
Sequence:
MEMEQEKMTMNKELSPDAAAYCCSACHGDETWSYNHPIRGRAKSRSLSASPALGSTKEFRRTRSLHGPCPVTTFGPKACVLQNPQTIMHIQDPASQRLTWNKSPKSVLVIKKMRDASLLQPFKELCTHLMEENMIVYVEKKVLEDPAIASDESFGAVKKKFCTFREDYDDISNQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKELRGKKTAVHNGLGENGSQAAGLDMDVGKQAMQYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSICVRDPVSDWFESLAQCLHWNVRKKQAHFEEEEEEEEEG
  
Inhibitor
Name:
BDBM50295365
Synonyms:
CHEMBL562056 | Di(8-bromoadenosine-5'-yl)disulfide
Type:
Small organic molecule
Emp. Form.:
C20H22Br2N10O6S2
Mol. Mass.:
722.39
SMILES:
Nc1ncnc2n([C@@H]3O[C@H](CSSC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n4c(Br)nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(Br)nc12 |r|
Structure:
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