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Target
Mu-type opioid receptor
Ligand
BDBM50167091
Substrate
n/a
Meas. Tech.
ChEMBL_302913 (CHEMBL830373)
Ki
15.1±n/a nM
Citation
 Van den Eynde, I; Laus, G; Schiller, PW; Kosson, P; Chung, NN; Lipkowski, AW; Tourwé, D A new structural motif for mu-opioid antagonists. J Med Chem 48:3644-8 (2005) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50167091
Synonyms:
CHEMBL192278 | N-{(S)-2-[(R)-2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propyl]-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl}-2-phenyl-acetamide
Type:
Small organic molecule
Emp. Form.:
C29H33N3O3
Mol. Mass.:
471.5906
SMILES:
Cc1cc(O)cc(C)c1C[C@@H](N)CN1Cc2ccccc2C[C@H](NC(=O)Cc2ccccc2)C1=O
Structure:
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