Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM50167290
Substrate
n/a
Meas. Tech.
ChEMBL_303351 (CHEMBL839666)
Ki
1.3±n/a nM
Citation
 Barrett, DG; Deaton, DN; Hassell, AM; McFadyen, RB; Miller, AB; Miller, LR; Payne, JA; Shewchuk, LM; Willard, DH; Wright, LL Acyclic cyanamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett 15:3039-43 (2005) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50167290
Synonyms:
(1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-isopropylhydrazinecarboxylate | CHEMBL371420
Type:
Small organic molecule
Emp. Form.:
C14H25N3O2
Mol. Mass.:
267.3672
SMILES:
C[C@@H](CC1CCCCC1)OC(=O)NN(C#N)C(C)C
Structure:
Search PDB for entries with ligand similarity: