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Target
Protein mono-ADP-ribosyltransferase TIPARP
Ligand
BDBM431646
Substrate
n/a
Meas. Tech.
ChEMBL_2210627 (CHEMBL5123576)
IC50
3.0±n/a nM
Citation
 Nizi, MG; Maksimainen, MM; Murthy, S; Massari, S; Alaviuhkola, J; Lippok, BE; Sowa, ST; Galera-Prat, A; Prunskaite-Hyyryläinen, R; Lüscher, B; Korn, P; Lehtiö, L; Tabarrini, O Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15. Eur J Med Chem 237:0 (2022) [PubMed] 
Target
Name:
Protein mono-ADP-ribosyltransferase TIPARP
Synonyms:
ADP-ribosyltransferase diphtheria toxin-like 14 | ARTD14 | PARP-7 | PARP7 | PARPT_HUMAN | Poly [ADP-ribose] polymerase 7 | TCDD-inducible poly [ADP-ribose] polymerase | TIPARP
Type:
Protein
Mol. Mass.:
76228.44
Organism:
Human
Description:
Q7Z3E1
Residue:
657
Sequence:
MEMETTEPEPDCVVQPPSPPDDFSCQMRLSEKITPLKTCFKKKDQKRLGTGTLRSLRPILNTLLESGSLDGVFRSRNQSTDENSLHEPMMKKAMEINSSCPPAENNMSVLIPDRTNVGDQIPEAHPSTEAPERVVPIQDHSFPSETLSGTVADSTPAHFQTDLLHPVSSDVPTSPDCLDKVIDYVPGIFQENSFTIQYILDTSDKLSTELFQDKSEEASLDLVFELVNQLQYHTHQENGIEICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVFNDSQEHLERFYCNPENDRMRMKYGGQEFWADLNAMNVYETTEFDQLRRLSTPPSSNVNSIYHTVWKFFCRDHFGWREYPESVIRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILLPYLQTLGGVPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNLFHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFHGTSQDVVDGICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGSHGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI
  
Inhibitor
Name:
BDBM431646
Synonyms:
5-[[(2S)-1-(3-Oxo-3-[4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1- yl]propoxy)propan-2-yl]amino]-4-(trifluoromethyl)-2,3-dihydropyridazin-3-one | US10550105, Example 561 | US10550105, Example 661 | US10870641, Example 661 | US11014913, Example 661
Type:
Small organic molecule
Emp. Form.:
C20H23F6N7O3
Mol. Mass.:
523.4321
SMILES:
C[C@@H](COCCC(=O)N1CCN(CC1)c1ncc(cn1)C(F)(F)F)Nc1cn[nH]c(=O)c1C(F)(F)F |r|
Structure:
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