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Target
Adenosine kinase
Ligand
BDBM50167601
Substrate
n/a
Meas. Tech.
ChEMBL_304674 (CHEMBL877308)
IC50
115±n/a nM
Citation
 Perner, RJ; Lee, CH; Jiang, M; Gu, YG; Didomenico, S; Bayburt, EK; Alexander, KM; Kohlhaas, KL; Jarvis, MF; Kowaluk, EL; Bhagwat, SS Synthesis and biological evaluation of 6,7-disubstituted 4-aminopyrido[2,3-d]pyrimidines as adenosine kinase inhibitors. Bioorg Med Chem Lett 15:2803-7 (2005) [PubMed]  Article 
Target
Name:
Adenosine kinase
Synonyms:
ADK | ADK_HUMAN
Type:
PROTEIN
Mol. Mass.:
40545.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1467841
Residue:
362
Sequence:
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH
  
Inhibitor
Name:
BDBM50167601
Synonyms:
7-{4-[((E)-2-Pyridin-2-yl)-vinyl]-phenyl}-6-p-tolyl-pyrido[2,3-d]pyrimidin-4-ylamine | CHEMBL193122
Type:
Small organic molecule
Emp. Form.:
C27H21N5
Mol. Mass.:
415.4891
SMILES:
Cc1ccc(cc1)-c1cc2c(N)ncnc2nc1-c1ccc(\C=C\c2ccccn2)cc1
Structure:
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