Reaction Details Report a problem with these data
Target
Adenosine kinase
Ligand
BDBM50167604
Substrate
n/a
Meas. Tech.
ChEMBL_304674 (CHEMBL877308)
IC50
433±n/a nM
Citation
 Perner, RJ; Lee, CH; Jiang, M; Gu, YG; Didomenico, S; Bayburt, EK; Alexander, KM; Kohlhaas, KL; Jarvis, MF; Kowaluk, EL; Bhagwat, SS Synthesis and biological evaluation of 6,7-disubstituted 4-aminopyrido[2,3-d]pyrimidines as adenosine kinase inhibitors. Bioorg Med Chem Lett 15:2803-7 (2005) [PubMed]  Article 
Target
Name:
Adenosine kinase
Synonyms:
ADK | ADK_HUMAN
Type:
PROTEIN
Mol. Mass.:
40545.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1467841
Residue:
362
Sequence:
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH
  
Inhibitor
Name:
BDBM50167604
Synonyms:
7-(4-Dimethylamino-phenyl)-6-phenethyl-pyrido[2,3-d]pyrimidin-4-ylamine | CHEMBL189971
Type:
Small organic molecule
Emp. Form.:
C23H23N5
Mol. Mass.:
369.4622
SMILES:
CN(C)c1ccc(cc1)-c1nc2ncnc(N)c2cc1CCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: