Reaction Details Report a problem with these data
Target
Adenosine kinase
Ligand
BDBM50167590
Substrate
n/a
Meas. Tech.
ChEMBL_304761 (CHEMBL829358)
IC50
>1000±n/a nM
Citation
 Perner, RJ; Lee, CH; Jiang, M; Gu, YG; Didomenico, S; Bayburt, EK; Alexander, KM; Kohlhaas, KL; Jarvis, MF; Kowaluk, EL; Bhagwat, SS Synthesis and biological evaluation of 6,7-disubstituted 4-aminopyrido[2,3-d]pyrimidines as adenosine kinase inhibitors. Bioorg Med Chem Lett 15:2803-7 (2005) [PubMed]  Article 
Target
Name:
Adenosine kinase
Synonyms:
ADK | ADK_HUMAN
Type:
PROTEIN
Mol. Mass.:
40545.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1467841
Residue:
362
Sequence:
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH
  
Inhibitor
Name:
BDBM50167590
Synonyms:
7-Thiophen-3-yl-6-p-tolyl-pyrido[2,3-d]pyrimidin-4-ylamine | CHEMBL189161
Type:
Small organic molecule
Emp. Form.:
C18H14N4S
Mol. Mass.:
318.396
SMILES:
Cc1ccc(cc1)-c1cc2c(N)ncnc2nc1-c1ccsc1
Structure:
Search PDB for entries with ligand similarity: