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Target
RNA-directed RNA polymerase
Ligand
BDBM50167631
Substrate
n/a
Meas. Tech.
ChEMBL_306492 (CHEMBL827995)
IC50
1900±n/a nM
Citation
 Pfefferkorn, JA; Nugent, R; Gross, RJ; Greene, M; Mitchell, MA; Reding, MT; Funk, LA; Anderson, R; Wells, PA; Shelly, JA; Anstadt, R; Finzel, BC; Harris, MS; Kilkuskie, RE; Kopta, LA; Schwende, FJ Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid. Bioorg Med Chem Lett 15:2812-8 (2005) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50167631
Synonyms:
CHEMBL365748 | N-[(Z)-2-[4-(2-Bromo-phenoxy)-phenyl]-1-(3-hydroxy-phenylcarbamoyl)-vinyl]-benzamide
Type:
Small organic molecule
Emp. Form.:
C28H21BrN2O4
Mol. Mass.:
529.381
SMILES:
Oc1cccc(NC(=O)C(\NC(=O)c2ccccc2)=C\c2ccc(Oc3ccccc3Br)cc2)c1
Structure:
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