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Target
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Ligand
BDBM50594239
Substrate
n/a
Meas. Tech.
ChEMBL_2211469 (CHEMBL5124418)
IC50
<10.0±n/a nM
Citation
 Li Petri, G; Di Martino, S; De Rosa, M Peptidomimetics: An Overview of Recent Medicinal Chemistry Efforts toward the Discovery of Novel Small Molecule Inhibitors. J Med Chem 65:7438-7475 (2022) [PubMed] 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Synonyms:
Enoyl - (acyl carrier protein) reductase | Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-acyl carrier protein reductase (FabI) | FABI_ECOLI | NADH-dependent enoyl-ACP reductase | envM | fabI
Type:
Enzyme
Mol. Mass.:
27861.12
Organism:
Escherichia coli
Description:
n/a
Residue:
262
Sequence:
MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNELELK
  
Inhibitor
Name:
BDBM50594239
Synonyms:
CHEMBL5200486
Type:
Small organic molecule
Emp. Form.:
C27H30N4O3
Mol. Mass.:
458.5521
SMILES:
CN(Cc1oc2ccccc2c1C)C(=O)\C=C\c1cnc2NC(=O)[C@@H](CCc2c1)N1CCCC1 |r|
Structure:
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