Reaction Details Report a problem with these data
Target
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Ligand
BDBM50594240
Substrate
n/a
Meas. Tech.
ChEMBL_2211469 (CHEMBL5124418)
IC50
<10.0±n/a nM
Citation
 Li Petri, G; Di Martino, S; De Rosa, M Peptidomimetics: An Overview of Recent Medicinal Chemistry Efforts toward the Discovery of Novel Small Molecule Inhibitors. J Med Chem 65:7438-7475 (2022) [PubMed] 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Synonyms:
Enoyl - (acyl carrier protein) reductase | Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-acyl carrier protein reductase (FabI) | FABI_ECOLI | NADH-dependent enoyl-ACP reductase | envM | fabI
Type:
Enzyme
Mol. Mass.:
27861.12
Organism:
Escherichia coli
Description:
n/a
Residue:
262
Sequence:
MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNELELK
  
Inhibitor
Name:
BDBM50594240
Synonyms:
CHEMBL5202156
Type:
Small organic molecule
Emp. Form.:
C28H33N5O4
Mol. Mass.:
503.5927
SMILES:
C[C@H]1CN(C[C@@H](C)O1)[C@@H]1CNc2cc(\C=C\C(=O)N(C)Cc3oc4ccccc4c3C)cnc2NC1=O |r|
Structure:
Search PDB for entries with ligand similarity: