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Target
Nociceptin receptor
Ligand
BDBM50167761
Substrate
n/a
Meas. Tech.
ChEMBL_302942 (CHEMBL841777)
Ki
2254±n/a nM
Citation
 Bartolomé, JM; Alcudia, A; Andrés, JI; Cid, JM; García, M; Megens, A; Toledo, MA; Trabanco, AA Novel 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo[b,f]furo[2,3-d]oxepin derivatives displaying combined norepinephrine reuptake inhibition and 5-HT2A/2C receptor antagonism. Bioorg Med Chem Lett 15:2898-901 (2005) [PubMed]  Article 
Target
Name:
Nociceptin receptor
Synonyms:
Nociceptin/Orphanin FQ, NOP receptor | Nociceptin/mu opioid receptor | OPRX_RAT | Oor | Oprl | Oprl1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40531.08
Organism:
RAT
Description:
Nociceptin/Orphanin FQ, NOP receptor 0 RAT::P35370
Residue:
367
Sequence:
MESLFPAPYWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASSLHREMQVSDRVRSIAKDVGLGCKTSETVPRPA
  
Inhibitor
Name:
BDBM50167761
Synonyms:
CHEMBL427007 | [8-((2S,3aS,12bS)-11-Bromo-2,3,3a,12b-tetrahydro-1,8-dioxa-dibenzo[e,h]azulen-2-ylmethyl)-7-oxa-8-aza-bicyclo[4.2.0]octa-1(6),2,4-trien-3-yl]-dimethyl-amine
Type:
Small organic molecule
Emp. Form.:
C25H23BrN2O3
Mol. Mass.:
479.366
SMILES:
CN(C)c1ccc2on(C[C@@H]3C[C@@H]4[C@H](O3)c3cc(Br)ccc3Oc3ccccc43)c2c1
Structure:
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