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Target
Mineralocorticoid receptor
Ligand
BDBM50167799
Substrate
n/a
Meas. Tech.
ChEMBL_304692 (CHEMBL876472)
IC50
7400±n/a nM
Citation
 Smith, CJ; Ali, A; Balkovec, JM; Graham, DW; Hammond, ML; Patel, GF; Rouen, GP; Smith, SK; Tata, JR; Einstein, M; Ge, L; Harris, GS; Kelly, TM; Mazur, P; Thompson, CM; Wang, CF; Williamson, JM; Miller, DK; Pandit, S; Santoro, JC; Sitlani, A; Yamin, TT; O'Neill, EA; Zaller, DM; Carballo-Jane, E; Forrest, MJ; Luell, S Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity. Bioorg Med Chem Lett 15:2926-31 (2005) [PubMed]  Article 
Target
Name:
Mineralocorticoid receptor
Synonyms:
MCR_RAT | MR | Mineralocorticoid Receptor (MR) | Mineralocorticoid receptor | Mlr | Nr3c2 | Nuclear receptor subfamily 3 group C member 2 | mineralocorticoid
Type:
Enzyme Catalytic Domain
Mol. Mass.:
106748.15
Organism:
RAT
Description:
mineralocorticoid 0 RAT::P22199
Residue:
981
Sequence:
METKGYHSLPEGLDMERRWSQVSQTLERSSLGPAERTTENNYMEIVNVSCVSGAIPNNSTQGSSKEKHELLPYIQQDNSRSGILPSDIKTELESKELSATVAESMGLYMDSVRDAEYTYDQQNQQGSLSPTKIYQNMEQLVKFYKENGHRSSTLSAMSRPLRSFMPDSAASMNGGALRAIVKSPIICHEKSSSVSSPLNMASSVCSPVGINSMSSSTTSFGSFPVHSPITQGTSLTCSPSVENRGSRSHSPTHASNVGSPLSSPLSSMKSPISSPPSHCSVKSPVSSPNNVPLRSSVSSPANLNNSRCSVSSPSNNTNNRSTLSSPTASTVGSIGSPISNAFSYATSGASAGAGAIQDVVPSPDTHEKGAHDVPFPKTEEVEKAISNGVTGPLNIVQYIKSEPDGAFSSSCLGGNSKISPSSPFSVPIKQESSKHSCSGASFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGSCEDSAFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSPRDQSFQHLSSFPPVNTLVESWKPHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGLHEEQPQQPPPPPPQSPEEGTTYIAPTKEPSVNSALVPQLTSITHALTPSPAMILENIEPETVYAGYDNSKPDTAESLLSTLNRLAAKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQLLYFAPDLVFNEEKMHQSAMYELCQGMRQISLQFVRLQLTFEEYSIMKVLLLLSTVPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNSSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESQALKVEFPAMLVEIITDQLPKVESGNAKPLYFHRK
  
Inhibitor
Name:
BDBM50167799
Synonyms:
1-(4-fluorophenyl)-4a-methyl-4',5'-divinyl-(4'R,4aS,5'R)-spiro[4,4a,5,6,7,8-hexahydro-1H-benzo[f]indazole-5,2'-(dihydro[1,3]dioxolane)] | CHEMBL382102
Type:
Small organic molecule
Emp. Form.:
C24H25FN2O2
Mol. Mass.:
392.4659
SMILES:
C[C@]12Cc3cnn(c3C=C1CCCC21O[C@H](C=C)[C@H](O1)C=C)-c1ccc(F)cc1 |c:9|
Structure:
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