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Target
Aurora kinase A
Ligand
BDBM50060898
Substrate
n/a
Meas. Tech.
ChEMBL_2211679 (CHEMBL5124628)
IC50
90±n/a nM
Citation
 Furqan, M; Fayyaz, A; Firdous, F; Raza, H; Bilal, A; Saleem, RSZ; Shahzad-Ul-Hussan, S; Wang, D; Youssef, FS; Al Musayeib, NM; Ashour, ML; Hussain, H; Faisal, A Identification and Characterization of Natural and Semisynthetic Quinones as Aurora Kinase Inhibitors. J Nat Prod 85:1503-1513 (2022) [PubMed] 
Target
Name:
Aurora kinase A
Synonyms:
AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK15 GN | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | Serine/threonine-protein kinase aurora-A | Synonyms=AIK | aurora-2 | hARK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Homo sapiens (Human)
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
  
Inhibitor
Name:
BDBM50060898
Synonyms:
5,8-Dihydroxy-[1,4]naphthoquinone | 5,8-dihydroxy-1,4-dihydronaphthalene-1,4-dione (7a) | 5,8-dihydroxy-1,4-naphthoquinone | CHEMBL274056 | naphthazalin
Type:
Small organic molecule
Emp. Form.:
C10H6O4
Mol. Mass.:
190.1522
SMILES:
Oc1ccc(O)c2C(=O)C=CC(=O)c12 |c:9|
Structure:
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