Reaction Details Report a problem with these data
Target
Hepcidin
Ligand
BDBM518194
Substrate
n/a
Meas. Tech.
ChEMBL_2212889 (CHEMBL5125838)
IC50
58±n/a nM
Citation
 Nguyen, MH; Atasoylu, O; Wu, L; Kapilashrami, K; Pusey, M; Gallagher, K; Lai, CT; Zhao, P; Barbosa, J; Liu, K; He, C; Zhang, C; Styduhar, ED; Witten, MR; Chen, Y; Lin, L; Yang, YO; Covington, M; Diamond, S; Yeleswaram, S; Yao, W Discovery of Novel Pyrazolopyrimidines as Potent, Selective, and Orally Bioavailable Inhibitors of ALK2. ACS Med Chem Lett 13:1159-1164 (2022) [PubMed] 
Target
Name:
Hepcidin
Synonyms:
HAMP | HEPC | HEPC_HUMAN | Hepc20 | Hepc25 | Hepcidin-20 | Hepcidin-25 | LEAP-1 | LEAP1 | Liver-expressed antimicrobial peptide 1 | PLTR | Putative liver tumor regressor
Type:
PROTEIN
Mol. Mass.:
9416.20
Organism:
Homo sapiens
Description:
ChEMBL_117296
Residue:
84
Sequence:
MALSSQIWAACLLLLLLLASLTSGSVFPQQTGQLAELQPQDRAGARASWMPMFQRRRRRDTHFPICIFCCGCCHRSKCGMCCKT
  
Inhibitor
Name:
BDBM518194
Synonyms:
US11111247, Example 24
Type:
Small organic molecule
Emp. Form.:
C23H31N9O2
Mol. Mass.:
465.5513
SMILES:
COC(=O)N1C[C@H](C)N([C@H](C)C1)c1ncc2[nH]nc(-c3ccc(nc3)N3CCN(C)CC3)c2n1 |r|
Structure:
Search PDB for entries with ligand similarity: