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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Ligand
BDBM50594729
Substrate
n/a
Meas. Tech.
ChEMBL_2213963 (CHEMBL5127095)
IC50
10000±n/a nM
Citation
 Hafez, N; Modather El-Awadly, Z; Arafa, RK UCH-L3 structure and function: Insights about a promising drug target. Eur J Med Chem 227:0 (2022) [PubMed] 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Synonyms:
UCHL3 | UCHL3_HUMAN | Ubiquitin C-terminal Hydrolase L3 (UCH-L3) | Ubiquitin thioesterase L3
Type:
Hydrolase; protease
Mol. Mass.:
26168.69
Organism:
Homo sapiens (Human)
Description:
Human recombinant UCH-L3 was purchased from Boston Biochem, Inc.(Cambridge, MA).
Residue:
230
Sequence:
MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERARYLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGETSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA
  
Inhibitor
Name:
BDBM50594729
Synonyms:
CHEBI:27485 | CHEMBL1397260
Type:
Small organic molecule
Emp. Form.:
C20H30O4
Mol. Mass.:
334.4498
SMILES:
CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)C=CC1=O |c:20|
Structure:
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