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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Ligand
BDBM50594730
Substrate
n/a
Meas. Tech.
ChEMBL_2213964 (CHEMBL5127096)
IC50
5000±n/a nM
Citation
 Hafez, N; Modather El-Awadly, Z; Arafa, RK UCH-L3 structure and function: Insights about a promising drug target. Eur J Med Chem 227:0 (2022) [PubMed] 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Synonyms:
UCHL3 | UCHL3_HUMAN | Ubiquitin C-terminal Hydrolase L3 (UCH-L3) | Ubiquitin thioesterase L3
Type:
Hydrolase; protease
Mol. Mass.:
26168.69
Organism:
Homo sapiens (Human)
Description:
Human recombinant UCH-L3 was purchased from Boston Biochem, Inc.(Cambridge, MA).
Residue:
230
Sequence:
MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERARYLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGETSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA
  
Inhibitor
Name:
BDBM50594730
Synonyms:
CHEMBL5193983
Type:
Small organic molecule
Emp. Form.:
C25H22N4O8
Mol. Mass.:
506.4642
SMILES:
COC(=O)c1cc(c(N)c(n1)-c1ccc2C(=O)C(OC)=C(N)C(=O)c2n1)-c1ccc(OC)c(OC)c1O |t:20|
Structure:
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