Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM50594736
Substrate
n/a
Meas. Tech.
ChEMBL_2213969 (CHEMBL5127101)
IC50
670±n/a nM
Citation
 Hafez, N; Modather El-Awadly, Z; Arafa, RK UCH-L3 structure and function: Insights about a promising drug target. Eur J Med Chem 227:0 (2022) [PubMed] 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1
Type:
PROTEIN
Mol. Mass.:
24819.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_974327
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM50594736
Synonyms:
CHEMBL5175498
Type:
Small organic molecule
Emp. Form.:
C18H14F3N5O
Mol. Mass.:
373.3319
SMILES:
FC(F)(F)c1[nH]ncc1-c1cccc2n(ccc12)C(=O)C1CCCN1C#N
Structure:
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