Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50168653
Substrate
n/a
Meas. Tech.
ChEMBL_303075 (CHEMBL828178)
Ki
2.8±n/a nM
Citation
Tran, JA; Pontillo, J; Arellano, M; Fleck, BA; Tucci, FC; Marinkovic, D; Chen, CW; Saunders, J; Foster, AC; Chen, C Structure-activity relationship of a series of cyclohexylpiperidines bearing an amide side chain as antagonists of the human melanocortin-4 receptor. Bioorg Med Chem Lett 15:3434-8 (2005) [PubMed] Article
More Info.:
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Inhibitor
Name:
BDBM50168653
Synonyms:
(R)-3-amino-N-(3-(2,4-dichlorophenyl)-1-(4-(1-((2-(4-methoxyphenyl)acetamido)methyl)cyclohexyl)piperazin-1-yl)-1-oxopropan-2-yl)propanamide | 3-Amino-N-{(R)-1-(2,4-dichloro-benzyl)-2-[4-(1-{[2-(4-methoxy-phenyl)-acetylamino]-methyl}-cyclohexyl)-piperazin-1-yl]-2-oxo-ethyl}-propionamide | CHEMBL364560
Type:
Small organic molecule
Emp. Form.:
C32H43Cl2N5O4
Mol. Mass.:
632.621
SMILES:
COc1ccc(CC(=O)NCC2(CCCCC2)N2CCN(CC2)C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)CCN)cc1